The Washington Post's Style Invitational asked readers to take any word from
the dictionary, alter it by adding, subtracting, or changing one letter, and
supply a new definition.
Here are some recent winners:

Intaxication: Euphoria at getting a tax refund, which lasts until you
realize it was your money to start with.

Reintarnation: Coming back to life as a hillbilly.

Giraffiti: Vandalism spray-painted very, very high.

Sarchasm: The gulf between the author of sarcastic wit and the person who
doesn't get it.

Inoculatte: To take coffee intravenously when you are running late.

Hipatitis: Terminal coolness.

Osteopornosis: A degenerate disease (this one got extra credit).

Karmageddon: It's like, when everybody is sending off all these really bad
vibes, right? And then, like, the Earth explodes and it's like, a serious
bummer.

Glibido: All talk and no action.

Dopeler effect: The tendency of stupid ideas to seem smarter when they come
at you rapidly.

And, the pick of the literature:
Ignoranus: A person who's both stupid and an asshole.